Flawless Execution

Process
Development

  • Robust Process Design
  • Safety Assessement
  • Analytical Development

Pilot
Manufacturing

  • Process Scale Up
  • Robust User Testing
  • Process Validation
  • Product Release

Commercial
Manufacturing

  • Process Validation
  • Commercial Supply
  • Product Release

Continuous investment means OmniChem can offer safe, high quality, process development, safety assessment and analytical development labs.

As an industry leader, when developing or scaling projects, OmniChem utilizes the latest analytical and statistical techniques to ensure the maximum speed without undue risk.

Key process analytical techniques include

  • FBRM Focused Beam Reflectance Measurement (Lasentec)
  • nIR gas, liquid and solid probes (Bruker)
  • Mid IR gas (Hamilton)
  • RAMAN liquid and solid (Kaiser)
  • Gas mass detector (Hiden)
  • Crystallisation Video Imaging (Sony/Polytec)
  • Turbidity (InPro)

Multiple Buchi Autoclaves for hydrogenation and pressure reactions

Crystallization investigations

  • Hot stage Microscope
  • Stereo Microscope
  • Crystal 16
  • Lab filter dryer
  • Filtration speed measurement

Evaporative Light Scattering Detectors

Corrosion testing

Parallel synthesis units (eg for preparation of validation: determination of normal  operation and proven acceptable ranges NOR/PAR)

Preparative HPLC (for impurity isolation and development of preparative separation processes) 

FlexyLab

The cornerstone of any product development effort is the analytical characterization and validation of all raw materials, in-process materials and finished product. OmniChem’s well-designed analytical programs satisfy regulatory requirements and work to assure the success of the development program. Analytical Scientists customize phase-appropriate analytical programs to the specific needs of your unique molecule delivering a comprehensive understanding and characterization of the molecule for each stage of development and commercialization.


Reference lots or standards are incorporated throughout the analytical program and are utilized as controls for assays used during the development and characterization of your product. Every time your drugs substance is manufactured, we compare your drugs substance against the standard to ensure it has comparable quality and purity.

World Leading Chemical Expertise

AZIDATION Use of azide to perform addition-, condensation-,  rearrangement- and substitution reactions . With strong focus on safety. Availability of in house developed softer azide reagents avoiding eliminations associated with NaN3.
CATALYTIC HYDROGENATION Selective and chiral reductions hydogenolysis – reductive alkylations hydrogenransfer reactions.
HYDRIDE REDUCTIONS Selective and stereoselective reactions with hydride donors under controlled reaction conditions in low temperature facilities (-100°C).
ORGANOMETALLIC CHEMISTRY Alkylations and coupling reactions using various lithium and magnesiumalkyls in a wide temperature range (-100°C to +100°C).
OXIDATION CHEMISTRY Selective and well monitored reactions involving peroxides, peracids, nitric and nitrous acids; controlled oxidations at low temperature (-100°C).
HIGH ENERGY REACTIONS Different types of energetic reactions (Diazonium reactions, nitrations, ….) to construct key building blocks.
COMPLEX CHEMISTRY (Hemi-)synthesis of alkaloids, sugars, multi stage reactions.

World Leading Technical Expertise

Handling of energetic reactions (azides, nitrations, …)

  • Safety is guaranteed by using extensively different types of process analytical technologies (PAT) in the liquid and gas phases

> 30,000 L of cryogenic capacity

  • Low temperature organometallic reactions
  • Low temperature oxidation reactions

> 22,000 L pressure vessels

  • Pressure hydrogenations but also other pressure reactions (CO, NH3, …)

Expertise in handling metal hydrides (NaBH4, LiAlH4, BH3-complexes, …)

Wide range of HAPI capacity (down to 0.1 ug/m3/8 hr)

Preparative HPLC (150 and 450 mm columns)

Pin and jet mill micronization

Analytical support with HPLC, UPLC, GC, UPLC-MS, GC-MS, NMR, ICP-MS, different techniques for particle size measurement assures. Where needed the analytical team will develop and validate new analytical methods.